环杓后肌失神经及神经再支配后兴奋性的研究

Experimental Study on Excitability of Posterior Cricoarytenoid Muscle After Denervation and Reinnervation

为研究环杓后肌失神经及其神经再支配后的兴奋性,将15只狗分成3组即神经植入组、神经肌蒂组及对照组,每组5只.术后6个月发现植入神经、带肌蒂的神经均与正常喉返神经兴奋性无显著性差异(P>0.05),且神经兴奋性高于肌肉兴奋性.两个恢复神经再支配组的环杓后肌与正常环杓后肌兴奋性亦无显著性差异(P>0.05),而失神经的环杓后肌与两个神经修复组及正常环杓后肌的兴奋性则有高度显著性差异(P<0.01),且其兴奋性最低.结果表明,当功能性电刺激治疗双侧喉返神经麻痹时,刺激电极安放在修复的神经上比安放在环杓后肌处效果要好.

To study excitability of posterior cricoarytenoid muscle after denervation and rein-nervation.15 dogs were divided into three groups:nerve implanted(5/15).nerve-muscle pedicle(5/ 15) and control group(5/15). After six months,the excitability values showed no significant difference among implant nerve,nerve of muscle-pedicle and intact recurrent laryngeal nerve(P>0. 05). The nerve excitability value was higher than that of muscle. The excitability values also demonstrated no significant difference between reinnervated muscles and normal muscles (P>0. 05). Significant difference was found between denervated and reinnervated muscles(P<0. 01),and the excitability values of denervated muscles were lowest. The conclusion was that stimulating electrodes placed on reinnervated nerve showed better result than that placed on denervated muscle in treating recurrent laryngeal nerve paralysis.