摘要
目的研究熊果苷(Arbutin,Arb)与甘草酸(Glycyrrhizin,GL)合用对免疫性炎症的治疗作用。方法观察Arb与GL合用对佐剂性关节炎及噁唑酮引起的小鼠耳肿胀的影响;测定Arb与GL合用大鼠炎性组织前列腺素E2(PGE2)含量及腹腔巨噬细胞释放白三烯B4(LTB4)的相对含量。结果Arb与GL合用对福氏全佐剂诱发的大鼠原发性及继发性足肿胀具有抑制作用;Arb和GL合用组对噁唑酮引起的小鼠两耳肿胀有抑制作用,且合用组小鼠血中CD4+T细胞明显降低;GL(400mg/kg)组及合用组PGE2相对含量显著低于模型组,合用组PGE2相对含量与GL(400mg/kg)组比较差异无统计学意义;两药合用可抑制大鼠腹腔巨噬细胞释放LTB4。结论Arb与GL对免疫性炎症具有协同治疗作用。
Objective To study the therapeutic effect of arbutin combined with glycyrrhizin on immune-inflammation. Methods The effect of arbutin combined with glycyrrhizin on adjuvant arthritis and on oxzolone induced mice ear swelling were investigated. PGE2 level in inflammatory tissue and LTB4 content from peritoneal macrophage of rat treated with arbutin and glycyrrhizin were determined. Results Arbutin combined with glycyrrhizin could inhibit Freund's complete adjuvant induced rat primary and secondary foot sweUing. The combined group could also inhibit oxazolone induced mice ear swelling and decrease CD4^+ T cell in blood. Compared with control group, PGE2 level in combined group was remarkable lower, and there was no difference between combined group and GL 400 mg/kg group. Arbufin combined with glycyrrhizin could inhibit LTB4 release from rat peritoneal macrophage. Conclusion Arbutin and glycyrrhizin has synergetic therapeutic effect on immune-inflammation.
出处
《中国中医药信息杂志》
CAS
CSCD
2009年第1期31-33,共3页
Chinese Journal of Information on Traditional Chinese Medicine
基金
浙江省教育厅科研项目(20030879)