摘要
在过去二十年里,对TH1和TH2细胞的分类构成了人们理解CD4+T细胞免疫学功能及它们在天然免疫和适应性免疫调节中作用的基础。近年来,新的免疫学理论认为初始T细胞可以在不同细胞因子及环境因素作用下分化为TH1、TH2、TH17和Treg细胞,几种效应细胞分别受到不同转录因子的调控,在体内产生不同的生物学功能。TH17细胞的发现更多的是与自身免疫性疾病的研究相关,它是T细胞分化过程中一种特殊的细胞亚群。初始T细胞在TGF-β和IL-6共同作用下分化为TH17细胞,同时它的分化受体内多种因素的调控。本文将从效应T细胞TH1和TH2、Treg细胞及DC细胞等对TH17细胞分化影响的角度分析TH17分化及其调控机制,这将对深入理解TH17细胞形成、分化和体内调控,并为自身免疫疾病和炎症冶疗提供一定的理论依据。
In the past 20 years, the TH1 and TH2 cell classification has provided the basic knowledge for CD4^＋T cell differentiation and interplay between innate and adaptive immunity. Until recently, novel immune studies have proved that, under the condition of different cytokines and environmental factors, innate T cell can be differentiated into several CD4^＋T cell effectors TH1, TH2, TH17 and Treg cell, which are controlled by their respective transcription factors and may thus play important roles in the body. The uncover on the differentiation of TH17 cell may be related to the research on auto-immunity research. And TH17 lineage can be controlled by several factors in the body, for example, it can be induced from innate T cell by the control of beth TGF-13 and IL-6. In this paper, different regulative mechanism for TH17 differentiation, including T cell effectors TH1, TH2, Treg cell and DC cell, will be reviewed. This promises to deepen the understanding on the new CD4^＋ T cell subset and its immune regulation, and may provide important basic knowledge for the treatment on auto-immunity and inflammation.
出处
《科技通报》
北大核心
2009年第1期45-50,共6页
Bulletin of Science and Technology
基金
浙江省自然科学基金资助项目(M303749)
