血清淀粉样蛋白A在呼吸系统疾病中的研究进展

Research advances of serum amyloid A in respiratory systemic diseases

血清淀粉样蛋白A（serum amyloidA，SAA）是一个非常敏感的急性时相蛋白。研究发现SAA与C-反应蛋白相比，其灵敏度、特异度更高，尤其病毒感染时其血清水平显著升高，而C-反应蛋白血清水平基本正常或轻度升高。其研究涉及呼吸系统多种疾病，如：上呼吸道感染、急性气管支气管炎、肺炎、慢性阻塞性肺疾病、肺癌、过敏性鼻炎和支气管哮喘、肺结核、肺囊性纤维化、肺结节病；此外在淀粉样变性、自身免疫性疾病、移植及心血管疾病中也有广泛研究。

Serum amyloid A（SAA） is an extremely sensitive acute phase protein. Reasearch found that SAA is higher than C-reactive protein（CRP） in sensitivity and specificity. SAA is strikingly elevated especially when body is infected by virus,however,CRP is basically normal or a little higher. SAA is studied in lots of respiratory systemic diseases, such as：upper respiratory tract infections, acute tracheobronchitis, pneumonia, chronic obstructive pulmonary disease, pulmonary carcinoma, allergic rhinitis and bronchial asthma,pulmonary tuberculosis, cystic fibrosis, pulmonary sareoidosis; SAA is also extensively studied in amyloidosis,autoimmune diseases, transplantation and cardiovascular diseases.