β-氟-α,β-不饱和酯的绿色合成

Synthesis of β-Fluoro-α,β-unsaturated Ester

研究了在无溶剂条件下羰基化合物、溴氟乙酸乙酯和三苯基膦三组分的"一锅法"反应,制备了一系列的β-氟-α,β-不饱和酯.本合成方法具有简便、原料价格便宜、反应快速、产率较高、对环境污染小等优点.

β-fluoro-α,β-unsaturated esters were obtained through ＂one-pot＂ reaction under solvent-free conditions. The reactions can undergo smoothly with high yields and easy-handing procedure. The reaction did not require the use of any volatile organic solvents, which is an economical and environmental friendly method for the synthesis of β-fluoro-α,β-unsaturated ester