地中海贫血孕期预防、治疗临床研究

The study of mediterranean anemia for screening methods and prevetion and treatment during pregnance

目的:探讨妊娠合并地中海贫血筛查的方法、预防及临床治疗。方法:选择2005年1月～2007年1月在我院妇产科门诊进行常规定期产前检查孕28周前在本院常规产检并住院分娩病例共700例。依据首次产前检查时血常规及血红蛋白结果分为3组。地贫组在补充叶酸、维生素E、复合维生素B,各2周,并指导孕妇均衡饮食,重新复查血常规及血红蛋白。结果:地贫组红细胞平均体积(MCV)及平均红细胞血红蛋白含量(MCH)明显低于非地贫组和对照组(P<0.01),而RBC计数明显高于后两组(P<0.01)。在给予叶酸、维生素E、复合维生素B后,28周及孕32周的地贫组孕在血常规RBC、Hb、MCV、MCH与初检时有统计学差异(P<0.05)。结论:孕期血细胞分析、血红蛋白电泳和基因诊断等方法可以有效并且准确筛查地中海贫血,通过补充叶酸、维生素E、复合维生素B,各2周,并指导孕妇均衡饮食,是可以改善临床症状的,从而保证优生优育。

Objective： To evaluate the value of the screening methods and the preventions and treatment of mediterranean anemia in pregnant women. Methods： Choosing 700 out-patients from 2005 to 2007 who participated in examination before delivery. Then divided them into three groups refering to the level of Hb. After being given vitamins and folic acid and regulated the food patients take. Checked the biochemiacal exams after 3 weeks. Results： The MCV and MCH in mediter- ranean anemia group（MA） were significant lower than controlled group and non-MA group （P〈0.01）, and RBC counting was higher than the other groups. After 3 weeks treatment, the RBC, Hb, MCV, MCH of patients had statistic difference from the first. Conclusion： As to the pregnant women, it is necessary and crucial to have the check about mediterranean anemia, and then take action efficiently for the purpose of health baby.