不同地区猪源和禽源大肠杆菌耐药性监测

Surveillance of Antimicrobial Resistance Among Escherichia coli Isolates from Swine and Poultry in Different Regions

2003--2005年自我国6省1市分离鉴定出133株猪源和455株禽源大肠杆菌临床株．采用微量肉汤稀释法测定了对20种抗菌药物的敏感性．结果表明，无论猪源还是禽源大肠杆菌对12种喹诺酮类药物耐药率非常高（耐药率范围34．96％-96．71％），对8种非喹诺酮类药物（除阿米卡星呈较低的耐药率外）也呈较高的耐药率（22．42％-94．07％）；多重耐药现象十分严重，3耐及3耐以上菌株占总菌株94％以上；不同地区来源菌株的耐药模式总体一致，但存在耐药水平高低的差异．

A total of 588 Escherichia coli isolates （133 from swine and 455 from poultry） were collected from six provinces and one city in China between 2003 and 2005. Antimicrobial susceptibility tests for 588 E. coli isolates were performed using broth microdilution method according to the recommendation of the Clinical and Laboratory Standards Institute （CLSI）. The results showed that resistance rates to 12 quinolones were very high, ranging from 34.96% to 96.71%o among 588 E. coli isolates. Except amika- cin, resistant incidence to eight non-quinolones was rather high, ranging from 22. 42% to 94.07%. Multi-drug-resistance was very severe and more than 94% of the 588 isolates exhibited multiple resistance to 3 or more antimicrobial agents. Resistance patterns were similar among E. coli isolates from different regions. However the resistance levels were significantly differed from different regions.