经冠状动脉自体骨髓单个核细胞移植治疗前壁心肌梗死的临床研究

Clinical study of autologous intracoronary bone marrow mononuclear cells transplantation in patients with anterior myocardial infarction

目的评价经冠状动脉内注射自体骨髓单个核细胞治疗前壁心肌梗死的有效性。方法共有39例前壁心肌梗死患者人选本组，其中23例为细胞移植组，16例为对照组。两组患者均接受标准的介入治疗和药物治疗，细胞移植组患者同时接受自体骨髓单个核细胞移植。两组患者均接受6个月的临床随访及6min步行试验和超声心动图检查。结果6个月的检查结果提示，细胞移植组患者的左室射血分数与常规治疗组相比有显著统计学差异。结论经冠状动脉注入自体骨髓单个核细胞可以促进前壁心肌梗死患者左室功能恢复。

Objective To evaluate the efficacy of autologous intracoronary bone marrow mononuclear cells （BMMNCs） transplantation to patients with anterior myocardial infarction （MI）. Methods Thirty - nine patients with MI （ 〉4 weeks） were enrolled in this study （23 patients in cell transplantation group; 16 patients in control group）. All patients were treated by standard drug therapy and percutaneous coronary intervention （PCI）. Baseline and 6 months follow - up evaluations included complete clinical and laboratory examinations, six minutes walk test, echocardiography. Results Baseline parameters were similar between the two groups NYHA classification and six minutes walk test at 6 months follow - up were also similar between the two groups. However, left ventricular ejection fraction （LVEF） determined by echocardiography. Conclusion Intracoronary BMMNCs transplantation could improve the left ventricular systolic function up to 6 months post transplantation in patients with myocardial infarction.