纤维素衍生物接枝聚乙二醇单甲醚生物材料的制备

Preparation of Cellulose Derivates Grafted Methoxy Polyethylene Glycol as Biomaterial

发现了一种制备纤维素衍生物接枝聚乙二醇衍生物的优良方法．首先以聚乙二醇单甲醚（MPEG）与溴乙酸乙酯反应制得羧甲基化聚乙二醇单甲醚（CMPEG），之后在N，N-二甲基乙酰胺／氯化锂（DMAc／LiCI）双组分非水溶剂体系中，以羰基二咪唑（CDI）为催化剂，通过CMPEG上的羧基与醋酸纤维素上残余的羟基进行酯化反应得到羧甲基化聚乙二醇单甲醚-醋酸纤维素接枝共聚物（CA-g-CMPEG）．用FTIR和DSC对产物进行了表征，结果表明，MPEG通过化学键偶联在醋酸纤维素分子的侧链上．用SEM观察了聚合物的形态，有自组装成粒子的趋向，粒径在200～300nm之间，是一种潜在的优良药物载体．

A good method was found to prepare CA-g-CMPEG. Carboxymethylate methoxy polyethylene glycol（CMPEG） was prepared through methoxy polyethylene glycol reactive with ethyl bromoacetate. CMPEG was introduced into acetate cellulose through a coupling reaction using N,N-carbony!diimidazole （CDI） as the catalyst in N,N-dimethylacetamide （DMAc）/LiCl. The product was analyzed by FTIR and DSC. Observation by SEM showed the morphologies of the product, and the average particle size was 200-300 nm. The graft copolymer is a potential drug delivery carrier.