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Smad7基因与肾间质纤维化 被引量：1

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摘要 肾间质纤维化（renal-interstitial fibrosis，IKIF）是由各种肾脏损害因素导致细胞外基质在肾间质内过度沉积的病理过程，是各种肾脏疾病发展到肾功能衰竭的共同通路和病理基础。因此，研究RIF的发病机制、干预RIF的进程是当前肾脏病界的研究热点。在RIF的各种发生机制中，转化生长因子β（tramforming growth factor～β，TGF～β）过度表达致肾纤维化的作用备受关注。TGF-β在RIF发生过程的多个阶段发挥了重要作用，是肾脏纤维化发生、发展中的关键因子。
作者 高岑 马跃荣
机构地区 泸州医学院病理教研室
出处 《泸州医学院学报》 2008年第6期658-661,共4页 Journal of Luzhou Medical College
关键词 肾间质纤维化 SMAD7基因 转化生长因子Β TGF-Β 细胞外基质 肾功能衰竭 肾脏纤维化 RIF
分类号 R692 [医药卫生—泌尿科学] R459.9 [医药卫生—治疗学]
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参考文献29

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二级参考文献27

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泸州医学院学报
2008年 第6期

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