摘要
肾小球硬化是多种肾脏疾病发展的最终结局，是以进行性的细胞外基质（ECM）堆积和肾小球固有细胞成分的减少为特征。机械因素、代谢因素以及多种调节分子等都与肾小球硬化的发生发展密切相关。足细胞是一种高度分化的细胞，分裂增殖能力有限，因此一旦损伤丢失，就很难再生。近年来随着多种足细胞标记蛋白的发现，国内外对足细胞在肾小球硬化中的研究日趋增多，大量研究提示足细胞损伤与缺失与肾小球硬化的关系密切，本文就近年来有关足细胞损伤引起肾小球硬化发病过程中的机制，作简要综述。
出处
《泸州医学院学报》
2008年第6期665-668,共4页
Journal of Luzhou Medical College
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