新型Hydantocidin类似物的研究进展

Progress on the Synthesis of Novel Hydantocidin Analogues

Hydantocidin是一个天然螺核苷类化合物,具有较高的内吸性除草活性,但对非靶标生物毒性低,极具开发潜力。近年来,人们对Hydantocidin的糖类、脱氧类似物、环二肽、交联结构类似物等新型衍生物的合成及生物活性进行了研究,并取得了丰富的研究成果。对这些新型Hydantocidin类似物的研究进展进行了综述。

Hydantocidin is the first natural spiro-nucleoside which was isolated from the culture broth of Streptomyces hygroscopicus SANK 63584. It exhibited potential herbicidal activity with efficiency similar to glyphosate against lots of weeds with high selective toxicity between plants and animals. Recently, the novel hydantocidin analogues including carbohydrate, deoxy, cyclopeptide, and hybrid analogues were synthesized and their activity was assayed. The progress on the research of these novel hydantocidin analogues was reviewed.