染砷大鼠子代脏器中砷的蓄积水平

Accumulative Arsenic Level in Viscera in Offsprings of Exposed Parent Rats

目的探讨砷在大鼠子代体内的代谢和蓄积情况。方法采用两代繁殖试验的方法，测定亲代大鼠接触不同剂量的砷后其子代脏器中砷的含量。结果心、肝、脑、肾和脾中砷的含量随染砷剂量的增加并呈正相关。以脾脏中砷含量最高。两代之间各脏器中砷含量差异无显著性。停止染砷后１个月，各剂量组脏器中砷含量均明显下降，但仍显著高于对照组。结论砷在大鼠子代体内有明显的蓄积作用并且砷从体内排出是一个缓慢的过程。

Objective To explore the metabolism and accumulation of arsenic in the offsprings of exposed rats. Methods Arsenic contents in viscera of the rat offsprings, whose parents exposed to different dose of arsenic, were determined with a two generation reproductive test. Results Arsenic contents in the heart, liver, brain, kidney and spleen of the offsprings correlated with the dose their exposed parents, the highest in the spleen. There was significant difference in arsenic contents of the viscera between two generations of rats. Arsenic contents in the viscera of the offsprings declined significantly one month after stopping exposure to arsenic, but still higher than that in controls. Conclusion It suggests that arsenic can deposit in the bodies of the rat offsprings, and excreted from the bodies slowly.