炎性因子与急性冠状动脉综合征相关性研究

The relationship between soluble CD40 ligand,myeloperoxidase,high sensitivity C-reactive protein and acute coronary syndrom

目的探讨可溶性CD40配体(sCD40L)、髓过氧化物酶(MPO)和高敏C反应蛋白(hs-CRP)等炎性指标与冠心病冠状动脉狭窄程度及病情严重度间的相关性。方法冠状动脉造影患者85例,按狭窄程度分无狭窄组、轻度狭窄组、中度狭窄组和重度狭窄组;按病情分为急性心梗(AMI)、不稳定型心绞痛(UAP)、稳定型心绞痛(SAP)和健康对照组。结果①血清sCD40L水平,AMI组[(16.42±4.66)ng/ml]与UAP组[(13.50±5.29)ng/ml]显著高于SAP组[(9.22±3.65)ng/ml]和对照组[(8.66±2.92)ng/ml]。②血清MPO水平,冠状动脉不同狭窄程度各组之间差异均存在显著统计学意义(F=25.95,P<0.001),AMI组[(156.61±33.63)U/L]显著高于UAP组[(92.06±42.11)U/L]、SAP组[(80.02±20.28)U/L]和健康对照组[52.33±14.32)U/L]。③hs-CRP水平,重度狭窄组略高于与无狭窄组(3.61±0.64比1.41±0.55,P<0.05);AMI组hs-CRP水平[(5.74±1.09)mg/L]显著高于UAP组[(1.91±0.72)mg/L,P<0.001]、SAP组[(2.61±0.60)mg/L,P<0.01]和对照组[(1.47±0.47)mg/L,P<0.001]。结论在冠心病不同程度冠脉狭窄组之间,血清MPO水平差异存在统计学意义,而sCD40L和hs-CRP水平差异无统计学意义;在冠心病不同程度病情组之间,血清sCD40L水平有统计学意义,而MPO和hs-CRP水平差异无统计学意义。

Objective To determine the relationship between sCD40L,MPO,hs-CRP and disease severity of coronary arteries. Methods 85 patients have been performed coronary angiography and test CD40, MPO,hs- CRP,were divided into four groups. Results （1）The serum sCD40L of group with serious stenosis （ 15.84±4.84ng/ ml）is significantly higher than other group （P〈0.05,0.01）. In the disease severity, the serum sCD40L in AMI [ （ 16.42±4.66）ng/ml] and in UAP[ （ 13.50±5.29）ng/ml] is significantly higher than in SAP[ （9.22±3.65）ng/ml] and control group [ （8.66±2.90）ng/ml ]. （2） The serum MPO have statistic differences between every two groups in all stenosis groups （F=25.95, P〈0.001 ）, the serum MPO in AMI [ （ 156.61＋33.63 ）U/L ] is significantly higher than in UAP [（92.06±42.11）U/L],in SAP [（80.02±20.28）U/L] and in control group [（52.33±14.32）U/L]. （3）The serum hs-CRP in serious stenosis group is slightly higher than in control group （3.61±0.64 vs 1.41±0.55,P〈 0.05）,there is no statistic differences between the other groups. The hs-CRP in AMI [（5.74＋1.09） rag/L] is significantly higher than in UAP[（1.91±0.72）mg/L,P〈0.01 ],in SAP[ （2.61±0.60）mg/L,P〈0.01 ] and in control group [ （1.47±0.47）mg/L,P〈0.01 ]. Conclusion The level of serum MPO have statistic differences among all stenosis groups of coronary heart disease, but sCD40L and hs-CRP have no statistic differences. The level of serum sCD40L have statistic differences in face of clinical severity, but MPO and hs-CRP have no statistic differences.