摘要
应用细胞培养、斑点杂交和荧光探针技术,观察到全反式维甲酸明显抑制胎牛血清诱导的血管平滑肌细胞表皮生长因子受体 mRNA 表达和[Ca^(2+)]_i 增加。
By techniques of cell culture,dot blot and fluorescent probe,it was observed that all trans retinoic acid(ATRA)can inhibit the mRNA expression of EGF receptor and the concentration of[Ca^(2+)]significantly in cultured rabbit vascular smooth muscle cells stimulated by fetal calf serum (FCS).
出处
《上海第二医科大学学报》
CSCD
1998年第2期100-102,共3页
Acta Universitatis Medicinalis Secondae Shanghai
基金
上海市高等学校科学技术发展基金项目(博士点基金)
关键词
全反式维甲酸
VSMC
EGF-R基因
动脉硬化
钙
all trans retinoic acid
vascular smooth muscle cell proliferation
EGF receptor gene
[Ca^(2+)]_i