SLE抗磷脂抗体阳性与HLA-DQA1相关分析

Correlation Between Antiphospholipid Antibodies and HLA-DQA1 in SLE

选用23名上海地区系统性红斑狼疮(SLE)抗磷脂抗体阳性(APA)患者,用 PCR-RFLP 方法作了 HLA-DQA1基因分型,同时以上海地区随机人群54例作为参照。结果表明:患者群中携带 DQA1*0103基因的例数为10例,基因频率为0.217;正常人群中有8例,基因频率为0.074。采用的2×2表独立性测验结果显示DQA1*0103对抗磷脂抗体阳性 SLE 的相对危险率(RR)为4.42,经校正的 x^2值为5.885,其 P 值介于0.01与0.02之间,表明 DQA1*0103与抗磷脂抗体阳性确有较强的关联。

23 APA positive SLE patients in Shanghai area were selected for HLA-DQA1 PCR-RFLP genotyping.Other 54 random-selected normal people were chosen as reference.Results show that there are 10 persons with DQA1*0103 in the patient group,thus the gene frequency is 0.217. Whereas there are 8 persons with DQA1*0.103 in the Shanghai referential group,thus the gene frequency of DQA1*0103 is 0.074.It is reported that the gene frequency of DQA1*0103 is 0.120 in northern China and 0.059 in southern China.It is obvious that the gene frequency of DAQ1*0103 of patients is much higher than that of northern China,southern China and Shanghai normal referential groups.2×2 independence test table shows that the relative risk(RR)of the SLE with APA positive is 4.42.The rectified value of X^2 is 5.885.The value of P is among 0.01 and 0.02.The result shows that HLA-DQA1*0.103 is strongly associated with APA positive in SLE.