摘要
探讨了给予二甲基亚硝胺(NDMN),同时补充β-胡萝卜素(β-C)后,大鼠体内抗氧化酶活性和脂质过氧化物含量的变化。结果显示,一定剂量的NDMN可使大鼠血红细胞、肝肾匀浆SOD活性和全血GSH-Px活性下降(P<0.05),血清和肝MDA和血清ROOH产生增多(P<0.05)。添加β-C(25mg/kg)后,SOD和GSH-Px活性均比单纯NDMN组有明显提高(P<0.05)。MDA和ROOH含量明显低于NDMN组(P<0.05)。提示自由基和脂质过氧化反应可能也是NDMN及其它亚硝胺致癌的途径之一;一定剂量的β-C可对抗NDMN引起的自由基和脂质过氧化。
The effect of β carotene (β C) on lipid peroxidation induced by N nitrosodimethylamine (NDMN) in rats was studied. Thirty clear conventional SD rats were randomly devided into 3 groups and were intragastricly given daily water (10ml/kg), NDMN(175mg/kg), and NDMN(175mg/kg) plus β C (25mg/kg) respectively. The results showed that: compared with group 1, the activities of SOD and GSH Px in NDMN group were significantly decreased (P<0.05), the values of MDA and ROOH increased (P<0.05). The activities of SOD and GSH Px in group 3 were significantly higher and the contents of ROOH and MDA were significantly lower than that of NDMN group (P<0.05). These results suggested that free radicals and lipid peroxidation may be a carcinogenic path for NDMN and other nitrosamines. β C had ability to inhibit the lipid peroxidation induced by NDMN.
出处
《卫生研究》
CAS
CSCD
北大核心
1998年第2期105-108,共4页
Journal of Hygiene Research
基金
广东省1995年医药卫生科学研究基金