氯化锰致家兔睾丸组织病理形态的改变

PathologicaI changes 0f testis in rabbits induced by manganese bichloride

目的：探讨锰对雄性生殖器官的毒性作用及损伤剂量。方法：成年雄性家兔经耳静脉亚慢性染毒不同剂量的MnCl2（0,0．1，0．5，2．0和8．0mp／kg），每周1次，连续染毒15周，观察睾丸组织形态学的变化。结果：各染毒组家兔睾丸组织Mn2+含量明显高于对照组（P＜0．05，0．01），并与染毒剂量呈正相关（γ=0．96，P＜0．05）；光镜检查发现，0．5～8．0mg／kg剂量组睾丸组织呈现间质水肿，曲细精管受损，数目减少，各级生精细胞不同程度变性、坏死及脱落，间质细胞数目减少等形态改变。结论：接触一定剂量的锰，可引起家兔睾丸组织形态学改变。

Objective: To probe into toxie effects on repreduction and damage doses of manganese. Meth- ods: The morphological changes of testis of adult male rabbits contadrinated with MnCl2 in different doses (0. 0,0. 1, 0. 5, 2. 0 and 8. 0 mg/kg weekly,about 15 weeks, iv) were observed. Results: The contents of Mi2+ in rab-bit testis treated with MnCl2 in different doses were significantly higher than those in control group (P<0. 05 or 0. 01 ); there was positive correlation between the content of Mn in testis and the contaminated dose of MnCl2 (γ=0. 96,P<0. 05);the edema of testicular mesenchyme,the damage and decrease of seminiferous tubles, the different degree of denaturation,necrosis and loss of every stage spermatogenic cells,the decrease of mesenchy-mal cells and so on were observed in 0. 5-8.0 mg/kg groups by light microscope. Conlusion: It is suggsted that exposure to a certain dose of manganese may induce the mophological changes of testis in rabbits.