失血性休克对肠道炎症反应和血红素加氧酶-1表达的影响

Hemorrhagic shock-induced gut inflammatory response and heme oxygenase-1 expression

失血性休克发生后，肠道功能首先受损，发生细菌移位和释放各种肠源性炎症介质，能够加重器官损害和功能不全，对全身炎症反应综合征和多器官功能不全综合征的发生有重要作用。同时，正常不分泌血红素加氧酶-1的肠道，在失血性休克期大量表达，具有重要的保护肠黏膜屏障功能稳定的作用，可以改善重要器官的功能，降低休克发生后的并发症和死亡率。但目前，还没有很好的方法来促进细胞大量表达血红素加氧酶-1。

Hemorrhagic shock induces damage of gut barrier function and a lot of gut-derived bacteria and inflammatory factors release which may induce distant organs injury and further aggravate systemic inflammatory response syndrome （SIRS） and multiple organs dysfunction syndrome （MODS）. Heme oxygenase-1 expression from the gut increases which dose not express physiologically. Many studies have demonstrated that heine oxygenase-1 expression is cytoprotective to attenuate the resultant organ injury and to decreases the morbidity and mortality rate. However, a useful way to up-regulate heine oxygenase-1 expression has not yet been found nowadays .