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滑石粉联合化疗药物治疗恶性胸腔积液的研究

Malignant pleural effusion treated with tale,fluorouracil and cisplatin
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摘要 目的探讨胸腔内注入滑石粉混悬液、顺铂(DDP)、氟尿嘧啶(5-FU)治疗恶性胸腔积液的疗效。方法病理确诊的恶性胸腔积液64例,经胸穿于胸腔内留置导管引流尽胸水后,随机分为2组:治疗组32例,在胸腔内注入滑石粉混悬液5~10 g、5-FU(500 mg/m^2)、DDP(40 mg/m^2);对照组32例,在胸腔内注入DDP (40 mg/m^2),均隔日重复1次,共2次。观察疗效、生活质量、生存率及毒副反应。结果治疗组总有效率84%,病变进展率3%,与对照组50%、22%相比有显著性差异(P<0.05)。Karnofsky评分大于70分,治疗组较对照组显著提高(P<0.05)。治疗组半年(0.5 a)、1年(1 a)、1年半(1.5 a)的生存率分别为97%、59%、44%,高于对照组的63%、50%、19%,0.5年、1.5年两组的生存率有显著性差异(P<0.05)。治疗组的副反应中发热、胸痛高于对照组。结论胸腔内联合注入滑石粉混悬液、5-FU、DDP治疗恶性胸腔积液是一种效果好、副反应轻、患者可耐受的方法。 Objective To evaluate the efficacy of treating malignant pleural effusion with the mixture of tale,5 - FU and DDP by injection through thoracic tube intubations. Methods Sixty - four cases of malignant pleural effusion, after drainage,were randomly divided into two groups: treatment group (T,32 cases) ,injecting tale (5 - 10 g), DDP (40 mg/m^2) and 5 -FU(500 mg/m^2) into pleural cavity;control group (C ,32 cases) ,only DDP (40 mg/m^2) ,which was repeated after one day,then evaluated the efficacy,survival rate,toxieities and the quality of life. Results The respondent was 84% in T group and 50% in C group. There was statistical differences between the two groups( P 〈 0.05 ). The Karnofsky score was higher in T group than these in C group. The half- year,one -year,one and half- year survival rates were 97% ,59% ,44% in T group and 63% ,50% , 19% in C group. Fever and pleura - ache were higher in T group than those in C group. Conclusions The treatment using tale,5 - FU and DDP through thoracic tube is effective, the side -effect is slight and is a bearable method for malignant pleural effusion.
出处 《医学信息(手术学分册)》 2008年第10期870-872,共3页 Medical Information Operations Sciences Fascicule
关键词 氟尿嘧啶 顺铂 滑石粉 恶性胸腔积液 tale fluomuracil cisplatin malignant pleural effusion
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