PET-CT联合肿瘤标志物诊断大肠癌术后转移

PET/CT combined with serum tumor markers detection in diagnosis of postoperative matastasis of colorectal cancer

目的探讨肿瘤标志物和正电子发射断层/计算机断层扫描(PET/CT)在大肠癌术后随访中的作用及相互关系。方法43例大肠癌术后病人做全身PET/CT检查,并在一周内检测血癌胚抗原(CEA)、肿瘤抗原19-9(CA19-9)、肿瘤抗原50(CA50)水平,并与最终诊断进行比较,分析两种检查之间差异和相互关系。结果43例中,27例诊断大肠癌转移。肿瘤标志物诊断大肠癌术后转移的敏感性为59.3%,特异性为87.5%;PET/CT诊断大肠癌术后转移的敏感性为92.6%,特异性为93.8%。两者联合诊断的敏感性为100%,特异性为82.1%。结论PET/CT诊断大肠癌术后的转移敏感性和特异性较肿瘤标志物检测高,肿瘤标志物对PET/CT诊断具有补充作用,两者联合应用是诊断大肠癌术后转移的比较理想的方法。

Objective To study the value of positron emission tomography/computcd tomography （PET/CT） and serum tumor markers in the follow-up of colorectal cancer after operation. Methods In 43 patients with surgical history of colorectal cancer,PET/CT was performed and serum earcinoembryonic antigen （CEA）, cancer antigen 19-9 （CA19-9） and cancer antigen 50 （CA50） were detected within the following week. The results were compared with the final diagnosis. Results The cancerometastases were found in 27 of 43 patients with the surgical history of coloreetal cancer. The sensitivity and specificity of tumor markers detection for diagnosis of metastasis were 59.3% and 87.5% ,which of PET/CT were 92.6% and 93.8% ,and of combined PE-F/CT with tumor markers detection were 100% and 82. 1%. Conclusion PET/CT has a higher sensitivity and specificity than tumor marker detection in assessment of postoperative matastasis of colorectal cancer, and tumor marker detection may be taken as a supplementary tool to PET/CT examination. Combined use of both examinations is an ideal strategy for detecting the metastases of colorectal cancer.