IGFBP-3、bFGF、Ki-67蛋白在非小细胞肺癌组织中的表达及意义

Expression and significance of IGFBP-3,bFGF and Ki-67 in non-small cell lung cancer

目的研究胰岛素样生长因子3(IGFBP-3)、碱性成纤维细胞生长因子(bFGF)、核增殖抗原(Ki-67)蛋白在非小细胞肺癌(NSCLC)中的表达及意义。方法应用免疫组化技术对60例NSCLC组织中IGFBP-3、bFGF、Ki-67抗原表达进行检测和分析。结果IGFBP-3、bFGF和Ki-67抗原表达率分别为71.67%(43/60)、56.67%(34/60)和68.33%(41/60);IGFBP-3和Ki-67表达与肿瘤分化程度、分期及淋巴结转移有关(P<0.05);bFGF表达与淋巴结转移及分期有关(P<0.05),与肿瘤的分化程度无关;三种标记的阳性表达与年龄、性别、组织类型无显著相关性(P>0.05)。IGFBP-3和bFGF、Ki-67的表达呈负相关(P<0.05)。结论在NSCLC组织中检测IGFBP-3、bFGF、Ki-67的表达对于判断NSCLC患者预后具有重要意义。

Objective To investigate the expression and significance of insulin-like growth factor-binding protein-3 （IGFBP-3）, bFGF and Ki-67 in human non-small cell lung cancer （NSCLC）. Methods The expressions of IGFBP-3, bFGF and Ki-67 were detected and analyzed in 60 cases with NSCLC by immunohistological technology. Results The positive rates of IGFBP-3, bFGF and Ki-67 were 71.67% （43/60）, 56. 67% （34/60） and 68.33% （41/60）, respectively. The positive rates of IGFBP-3 and Ki-67 were correlated with clinical stages, tumor differentiation and the lymph nodes metastasis （P〈0. 05）. The positive rate of bFGF was significantly higher in the cases with local nodal metastasis and higher clinical stages. The expression of IGFBP-3 was negatively correlated with that of bFGF and Ki-67 in NSCLC. Conclusion Detecting the expressions of IGFBP-3, bFGF and Ki-67It is of importence in predicting the prognosis of patients with NSCLC.