期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

放射抗拒性人鼻咽癌细胞系CNE-2R的建立 被引量：4

原文传递
导出
摘要 研究表明癌细胞经射线反复照射后能产生放射抗拒性，但鼻咽癌细胞是否可通过射线反复照射方法在分子水平获得稳定的具有放射抗拒性的新细胞系？研究拟以不同剂量反复照射人鼻咽低分化鳞癌细胞系CNE-2以期建立稳定的放射抗拒鼻咽癌细胞系CNE-2R，为研究鼻咽癌放射抗拒机理提供有力的研究工具。
作者 王亚利 王西京 王中卫 金迎迎 李毅
机构地区 西安交通大学医学院第二附属医院肿瘤科放疗中心
出处 《中华放射肿瘤学杂志》 CSCD 北大核心 2009年第1期80-81,共2页 Chinese Journal of Radiation Oncology
基金 基金项目：陕西省科技攻关项目[2007k09-09（8）]
关键词 人鼻咽癌细胞系 放射抗拒性 照射方法 CNE-2 鳞癌细胞系 分子水平
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献4

  • 1Murray D, McEwan AJ. Radiobiology of systemic radiation thera- py. Cancer Biother Radiopharm,2007,22:1-23.
  • 2Mitsuhashi N, Takahashi T, Sakurai H, et al. A radioresistant variant cell line,NMT-1R, isolated from a radiosensitive rat yolk sac tumour cell line, NMT-1 : differences of early radiation-induced morphological changes, especially apoptosis. Int J Radiat Biol, 1996,69:329-336.
  • 3许庆勇,徐向英,杨伟志.X线反复照射人肺癌细胞系Anip973后的生物特性变化[J].中华放射肿瘤学杂志,2008,17(1):51-54. 被引量：4
  • 4Tamulevicius P, Wang M, Iliakis G. Homology-directed repair is required for the development of radioresistance during S phase : interplay between double-strand break repair and checkpoint response. Radiat Res ,2007,167 : 1-11.

二级参考文献12

  • 1郭万峰,林汝仙,黄坚,郭国祯,王升启.辐射相关基因芯片的制备及其在肺癌细胞中的应用[J].中华放射医学与防护杂志,2005,25(2):107-110. 被引量：6
  • 2骆志国,周福祥,周云峰,代静,谢丛华,刘诗权.辐射诱导辐射耐受鳞癌细胞株的建立及其生物学特性[J].中华放射肿瘤学杂志,2005,14(3):208-212. 被引量：16
  • 3Javier F, Eschrich S, Zhao H, et al. Prediction of radiation sensitivity using a gene expression classifier. Cancer Res, 2005,65 : 7169- 7176.
  • 4Fukuda K, Sakakura C, Miyagawa K, et al. Differential gene expression profiles of radioresistant oesophageal cancer cell lines established by continuous fractionated irradiation. Br J Cancer, 2004,91 : 1543-1550.
  • 5Ogawa K, Utsunomiya T, Mimori K, et al. Differential gene expression profiles of mdioresistant pancreatic cancer cell lines established by fractionated irradiation. Int J Oncol,2006,28:705-713.
  • 6Wei K,Kodym R,Jin C. Radioresistant cell strain of human fibmsarcoma cells obtained after long-term exposure to X-rays. Radiat Environ Biophys, 1998,37 : 133-137.
  • 7Sinclair WK, Morton RA. X-ray sensitivity during the cell generation cycle of cultured Chinese hamster cells. Radiat Res, 1966,29:450- 474.
  • 8Kang CM, Cho HN, Ahn JM, et al. Alteration of gene expression during radiation-induced resistance and tumorigenesis in NIH333 cells revealed by cDNA microarrays: involvement of MDM2 and CDC25B. Carcinogenesis ,2004,25 : 123-132.
  • 9Dunne AL, Price ME, Mothersill C, et al. Relationship between clonogenic radiosensitivity, radiation-induced apoptosis and DNA damage/repair in human colon cancer cells. Br J Cancer,2003,89: 2277 -2283.
  • 10Olivieri G, Bodycote J, Wolff S. Adaptive response of human lymphocytes to low concentration of radioactive thymidine. Science, 1984, 223 : 594-597.

共引文献3

同被引文献39

  • 1朱小东,刘颖新,王安宇,梁世雄,陈发龙,罗元.p15、bcl-2及PCNA在不同放射敏感性的鼻咽癌组织中的表达及其相关性研究[J].肿瘤防治研究,2004,31(12):768-769. 被引量：3
  • 2程金建,胡震,夏云飞,陈忠平.人脑胶质瘤细胞株MGR2放射抗拒性的诱导[J].癌症,2006,25(1):45-50. 被引量：9
  • 3黄东海,田勇泉,邱元正,范松青,李桂源.应用PCNA和survivin预测鼻咽癌放疗敏感性的研究[J].同济大学学报（医学版）,2006,27(5):39-42. 被引量：14
  • 4Feng XP, Yi H, Li MY, et al. Identification of biomarkers for predicting nasopharyngeal carcinoma response to radiotherapy by proteomics[ J]. Cancer Res, 2010,70( 1 ) :3450-3462.
  • 5Geddes DM. The natural history of lung cancer: a review based on rates of turnout growth[J]. Br J Dis Chest, 1979,73(1) :1-17.
  • 6Pearce AG, Scgura TM, Rintala AC, et al. The generation andcharacterization of a radiation-resistant model sysem to study radioresistance in human breast cancer cells [ J]. Radiat Res, 2001,156 ( 1 ) :739-750.
  • 7Leung TW, Tung SY, Sze WK, et al. Treatment results of 1 070 patients with nasopharyngeal carcinoma: an analysis of survival and failure patterns [ J ]. Head Neck, 2005,27 (7) :555-565.
  • 8Wang CD, Huang JG, Gao X, et al. Fangchinoline induced GI/S arrest by modulating expression of p27, PCNA, and cyclin D in hu man prostate carcinoma cancer PC3 cells and tumor xenograft [ J ]. Biosci Biotechnol Biochem, 2010,74 ( 3 ) :488-493.
  • 9Wei QC,ShenL,ZhengS,eta1.Isolationandcharacterizationofradiation.resistantlungcancerD6.Rcellline『J].BiomedEnvironSci,2008,21(4):339-344.
  • 10GUO Y,ZHU XD,QU S,et al.Identification of genes involved in radioresistance of nasopharyngeal carcinoma by integrating gene ontology and protein-protein interaction networks[J].Int J Oncol,2012,40(1):85-92.

引证文献4

二级引证文献18

中华放射肿瘤学杂志
2009年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部