Wnt信号通路与成骨细胞

Wnt signaling pathway and osteoblast

经典Wnt信号通路在成骨细胞的发生及骨形成过程中扮演重要角色。研究表明上调或下调wnt通路中相关因子的表达或改变它们的功能，通过影响成骨细胞的发育、分化、骨基质的形成和矿化，间接影响破骨细胞的发生和骨吸收等，导致骨量减少或高骨量的变化。随着Wnt通路与成骨细胞发育及分化研究的深入，一系列新靶点的发现将有助于骨质疏松的治疗。笔者综述了目前Wnt通路与骨形成及相关疾病治疗的研究进展。

The Wnt/β-catenin or canonical Wnt pathway plays an important role in the control of osteoblastogenesis and bone formation. Studies showed that the dysregulation of signaling pathways that affects osteoblast or osteoclast differentiation and function leads to either osteopenia or high bone mass. After a deep research on the Wnt signaling pathway and osteoblast, a series of new targets of anti-osteoporosis will be discovered. In the present review we summarized the current progression on the various components of the Wnt signaling pathway and bone formation as well as related disease therapy.