87例药物性肝损伤的临床特点分析

Clinical Analysis of 87 Patients with Drug-Induced Hepatic Lesions

目的研究药物性肝损伤的病因及临床特点,从而提高临床医师对该病的认识。方法对2003-2008年在本院住院治疗的药物性肝损伤87例进行回顾性研究,分析其所用药物、临床表现和转归等特点。结果引起肝损伤的药物种类繁多,抗结核药物占首位,其次为抗甲状腺药物和解热镇痛药。肝损伤的临床表现无特异性。经正规的治疗后大多数可以得到满意的治疗效果,也有极少数出现肝衰竭。结论肝损伤的致病原因繁多,临床表现未发现特异性,也可导致严重后果,临床医师临床用药时应该注意监测肝功能。

Objective The aim of this study was to analyze the etiology and clinical features of drug-induced liver damage, and to increase the awareness of clinicians treating this disease. Methods Eighty-seven cases of druginduced liver damages between 2003 and 2008 in this hospital were retrospectively reviewed. The clinical features, efficacy and the drug used were analyzed. Results Liver damage may be caused by various drugs, in which antituberculosis drugs, anti-thyroid drugs and anti-pyretic analgesic drugs were the top three types of drugs causing liver damage. Special clinical feature associated the liver damage was not observed. Satisfactory treatment was seen with conventional therapy. Hepatic failure was observed in some cases. Conclusion Special clinical feature was not observed in patients with drug-induced liver damage. Liver function should be monitored before the prescription of certain drugs.