SOCS-2和SOCS-3通过IGF-1和GH信号转导系统作用于成肌细胞的分化(英文)

SOCS-2 and SOCS-3 are Related to Myoblast Differentiation via the IGF-1 and GH Signaling Transduction System

新近发现的细胞因子信号转导抑制因子(SOCS)家族,因其能够通过Janus激酶—信号传导和转录激活子(JAK-STAT)信号传导通路来反馈调节生长因子的信号或者抑制细胞因子的信号转导而倍受研究人员重视。一些研究表明,SOCS-3在促进成肌细胞分化和抑制白介素6(IL-6)导致的细胞炎症过程中具有重要的作用。综合大量关于细胞因子信号转导抑制因子家族的文献报道,文章分析了近几年SOCS-2和SOCS-3与IGF-1和GH信号转导关系的研究,特别是关于SOCS-3在成肌细胞分化过程中的研究,认为可以将SOCS-2和SOCS-3作为细胞内生长信号调节和促进动物肌肉发育的潜在因子进行研究。

A recently described family of proteins, the suppressor of cytokine signaling （SOCS） family, which acts in a negative feedback loop to regulate growth factor signaling or cytokine via the Janus kinase signal transducer and activator of transcription （JAK-STAT） pathway, has been much reported, and some studies suggest that SOCS-3 plays a key role in myoblast differentiation and suppressing of interleukin-6 mediated cellar inflammatory. With the bulk of reports about the SOCS family, this paper reviews the studies on the relevance of SOCS-2 and SOCS-3 to the IGF-1 （insulin-like growth factor 1） and GH （growth hormone） signaling system, especially focusing on the role of SOCs-3 in the myoblast differentiation. The results of the previous studies suggest that the SOCS-2 and SOCS-3 may be potential intercellular protein factors to act on the growth factor signaling and SOCS-3 probably has an accelerating effect on animal muscle development.