人参皂甙对大鼠脊髓损伤的实验研究

An Experimental Study Of Ginsenosides On The Treatment Of Spinal Cord Injure In Rats

目的观察人参皂甙(Ginsenosides,GS)对脊髓损伤大鼠模型脊髓继发性损伤的作用。方法80只大鼠随机分成四组。假实验组施行椎板切除但不损伤脊髓;其余三组均采用改良Allen法制备大鼠脊髓损伤模型,分别于术后不同时间段进行运动行为评分和斜板功能障碍评分。术后14 d处死大鼠取损伤节段标本行组织病理学检查。结果各组大鼠的脊髓功能均有不同程度的恢复,GS组和MP组运动行为评分和斜板功能障碍评分无明显差异(P>0.05),均与对照组有明显差异(P<0.05)。损伤节段病理学结果显示,GS组和MP组的脊髓继发性损伤轻于对照组。结论GS对脊髓损伤大鼠的脊髓功能具有保护作用。

Objective To investigate the protective effects of Ginsenosides on experimentally secondary injured spinal cord in rats.Meflaods eighty rats were randomly divided into four groups： sham operation group, SCI group, GS treatment group, and MP treatment group. Rats in sham operation group had only laminectomy performed and no spinal cord injury; rats in other three groups were injured at the level of T11 spinal segment of the rats by Allen＇ s weight drop method. The functional tests were performed at day 1,7 and 14.All injured rats were killed on the 14 day and the injured spinal cords were taken out for histological tests.Results The function of the spinal cord of rats in varying degrees to resume.In The functional tests,Rats in the GS and MP groups gained mere sigrtifieant rehabilitation than those in the control grnup （ P 〈 0.05）, while no significant difference was observed between the two groups （ P 〉 0.05）.It was revealed by pathological analysis is that in the GS and MP greups, Secondary injuries were less than the control group at the same points. Couclusion GS has some protective effects on spinal cord in rats.