天然抗菌肽的研究进展及应用前景

Progress in Investigation of Natural Antimicrobial Peptides and Application Prospect

天然抗菌肽是生物体内经诱导产生的一种具有抗菌活性的小分子多肽,来源广泛。目前已从多种物种中分离纯化出千余种抗菌肽,其分子量大约在3～6kD之间,由20～60个氨基酸残基组成。天然抗菌肽具有多种生物活性,如抗细菌、抗真菌、抗病毒和抗癌细胞等作用。综述了天然抗菌肽的分类、生物活性及其作用机理和应用前景。

Natural Antimicrobial peptides （AMPs）,a family of short-chain peptides with antibacterial activity,are widely spread in biological universe. At present,there are more than one thousand antimicrobial peptides that have been soluted and purified from many species, the molecular mass of which range from about 3-6kD and composing of 20-60 amino acids. Natural Antimicrobial peptides have many activities,such as antiviral activity,antifungal activity,antirnicrobial activity and anticancer activity. This article summarized the categorization,biological activiw,antibacterial mechanism and prospective application of natural antimicrobial peptides.