摘要
目的观察脑得生丸改善微循环、血液流变学相关药理作用。方法SD大鼠60只,雌雄各半,随机分为正常组,模型组,脑得生丸低、中、高剂量组,丹参滴丸组,每组10只。各组灌胃给予相应药物,qd,连续7d,正常组和模型组给予等体积纯化水。除正常组外,各组皮下注射盐酸肾上腺素注射液和放入冰水造血淤模型;观察耳廓、脑部、肠系膜微循环及改善血液流变学指标的药效学。结果脑得生丸能改善血瘀模型大鼠耳廓、脑部、肠系膜微循环,显著降低血淤模型大鼠全血黏度、红细胞聚集指数及变形指数,缩短红细胞电泳时间。结论脑得生丸具有改善微循环、血液流变学的作用。
Objective To investigate the pharmacological effect of naodesheng on improving microcirculation and hemortheology. Methods 60 SD rats were divided into the normal, model control, low dose, middle dose and high dose tested groups, which were treated with naodesheng pills qid for consecutive 7 d, except for the normal and model groups. The blood stasis rat model was established by s. c. adrenalin hydrochloride injection in ice bath. The minicirculation and hemortheology in auricle, brain and mesentery were observed. Results Naodesheng improved the blood viscosity in auricle, brain and mesentery and obviously reduced the acute syndrome of blood stasis, erythroytic accumulative index, deformed index and electrophoresis time. Conclusion Naodesheng may improve microcirculation and hemortheology of rats with blood stasis.
出处
《医药导报》
CAS
2009年第1期40-42,共3页
Herald of Medicine
关键词
脑得生丸
微循环
血液流变学
Naodesheng pill
Microcirculation
Hemortheology
