摘要
EB病毒潜伏膜蛋白1（LMP1）是EB病毒编码的一种主要蛋白，它能通过其C末端的3个功能结构域CTAR1、CTAR2及CTAR3启动一系列信号途径，包括核因子κB、PI3K-Akt／PAB、MAPK及JAKs／STATs，从而调节其宿主细胞的生长、增殖、分化、凋亡等多种细胞生物学功能，本文就这方面的研究进展及其自身调节的机制综述如下。
Epstein-Barr virus latent membrane protein 1 （ LMP1 ）, which is a major protein encoded by EB virus, can adjust growth, proliferation, differentiation, apoptosis and other biological functions of its host cell by launching a series of signal channels including the NF-κB, PI-3K-Akt/PKB ,MAPK and JAKs/STATs through its three functions of the C-terminal domain CTAR1, CTAR2 and CTAR3. This article reviews the related progress and its antogenous regulation mechanism.
出处
《医学综述》
2009年第2期170-173,共4页
Medical Recapitulate
关键词
潜伏膜蛋白
细胞信号
自身调节
Latent membrane protein 1
Cell signaling
Self-regulation
