胃癌组织中VEGF和iNOS的表达和意义

Expression and Significance of VEGF and iNOS in Gastric Carcinoma

目的研究胃癌组织中VEGF和iNOS的表达,探讨VEGF与iNOS的相关性。方法采用免疫组织化学S-P法检测85例胃癌组织和癌旁正常胃组织中的VEGF和iNOS的表达,并分析其相互关系。结果VEGF和iNOS在胃癌组织中的表达水平明显高于癌旁组织中的表达水平(P<0.05),VEGF和iNOS的表达与胃癌的临床TNM分期、浸润程度和淋巴结转移有关(P<0.05),与组织学分级无关(P>0.05),VEGF的表达和iNOS的表达呈正相关(γ=0.426,P<0.05)。结论VEGF与iNOS蛋白在胃癌组织中均有较高的阳性表达,且表达具有相关性,两者可能存在共同的激活机制。VEGF和iNOS的蛋白表达与胃癌的恶性进程有关。

Objective To investigate the expression of vascular endothelial growth factor（VEGF） and inducible nitric oxide synthase（iNOS） in gastric carcinoma（GC）, and to evaluate the correlation between the expression of VEGF and iNOS. Methods Using S-P immunohistochemical S-P method to detect the expression of VEGF and iNOS in 85 patients with gastic carinoma. Results The positive expression rates of VEGF and iNOS in GC were significantly higher than that in paired para-carcinoma tissues. There was significiat correlation between the expression of VEGF,iNOS and clinic TNM stage,invasive depth,lymph node metastasis （ P 〈 0. 05 ）, but there was no correlation between the expression of VEGF, iNOS and the pathological grade. Expression of VEGF was positively correlated with that of iNOS. Conlusion VEGF and iNOS are highly expressed and correlated in gastric carcinoma. It is speculated that a common activation mechanism may coexists between the two genes, VEGF protein and iNOS protein expression played an important role in the malignant progression of GC.