舌鳞状细胞癌复发相关因素分析

Analysis of Recurrence-related Clinicopathological Factors of the Patients with the Squamous Cell Carcinomaof the Oral Tongue

目的探讨影响舌鳞状细胞癌复发的相关因素。方法回顾性研究131例舌鳞状细胞癌患者的临床病理资料,采用χ2检验和Logistic回归模型分析11个临床病理因素与其复发的关系。结果局部和区域共复发57例,总复发率为43.5%,肿瘤体积为舌鳞癌复发的独立影响因素(P=0.000);区域复发34例,区域复发率为26.0%,颈部淋巴结转移与区域复发相关(χ2=11.603,P=0.001)。结论肿瘤体积是影响舌鳞癌复发的最重要因素,可作为评估舌鳞癌复发风险的指标之一;颈部淋巴结转移是舌鳞癌区域复发的重要影响因素,手术治疗应作为舌鳞癌颈部的主要治疗方法。

Objective To explore the recurrence - related factors of the squamous cell carcinoma of the oral tongue. Methods Clinicopathological data of 131 patients with the squamous cell carcinoma of the oral tongue were reviewed and analyzed. The correlations of 11 clinicopathological factors with tumor recurrence were analyzed by χ^2 test and Logistic regression analysis. Results 57 patients had localregional recurrence. The overall recurrence rate was 43.5%. Tumor volume was the independent factor influencing the recurrence of the squamous cell carcinoma of the oral tongue （ P = 0. 000）. Thirty - four patients had regional recurrence. The regional recurrence rate was 26.0%. Cervical lymphatic metastasis was related to the regional recurrence（χ^2 = 11. 603,P = 0. 001 ）. Conclusion Tumor volume was the most important factor influencing the recurrence of the squamous cell carcinoma of the oral tongue, and could be a factor that predicted the risk of recurrence. Cervical lymphatic metastasis was an important factor influencing the regional recurrence. Surgery should be the main therapeutic method for the neck of patients with the squamous cell carcinoma of the oral tongue.