针灸对环磷酰胺化疗小鼠脂质过氧化损伤的影响

INFLUNCE OF ACUPUNCTURE AND MOXIBUSTUION ON THEDAMAGE OF HYPERLIPOXIDE MICE WITH CTX CHEMOTHERAPY

环磷酰胺（ＣＴＸ）能损伤机体抗氧化系统，引发脂质过氧化损伤。实验对照组血清、肝组织ＳＯＤ活力分别为：２０５．０８±４６．７０，１３０．７７±４１．６９，与正常对照组（２９９．５８±３８．７５，３８３．６９±５１．７６）差别均有非常显著性意义（Ｐ＜０．０１），而其肝组织ＭＤＡ含量又明显高于正常对照组（Ｐ＜０．０１）。针灸能较好地保护机体的抗氧化系统，提高ＳＯＤ活力，减少脂质代谢产物在体内的堆积，减轻环磷酰胺对机体的毒副作用。各针灸组ＳＯＤ活力均不同程度地高于实验对照组。而其ＭＤＡ含量又明显低于实验对照组。针灸的效应与所选用的腧穴、刺激量、刺激方法有关。以足三里穴好于大椎、命门；针刺好于艾灸；针灸５分钟好于１０分钟。

Cyclophosphamide(CTX) can do harm to the antioxidie system of the body, which causes the damage of hyperlipoxide. In our research of SOD(in serum and liver) and MDA(in liver), the results show there are significant differences between the experimental and control groups (the SOD of former is lower, but MDA is higher).From the experiment, it is found that acupuncture can protect the antioxidice system of the body, improve the activity of SOD, decrease the accumulation of metabolism of lipin, lower the sideeffect of CTX. But the effects are coordinated with the points. (Zusanli is better than Dazui, Mingmen) stimulated degree(five minutes stimulation is better than ten) and the chosen method (Acupuncture is better than moxibustion).