新辅助化疗对乳腺癌细胞凋亡和增殖的影响

Effects of neoadjuvant chemotherapy on apoptosis and proliferation of breast cancer

目的探讨survivin和Ki-67在乳腺癌新辅助化疗中表达变化的意义。方法应用免疫组织法检测37例乳腺癌新辅助化疗前后标本中survivin和Ki-67表达。结果化疗前后survivin、Ki-67指数变化显著,分别由化疗前的67.57%和(67.27±12.17)%,降到化疗后的35.14%和(47.25±11.09)%(P<0.05)。survivin表达与Ki-67呈正相关(P<0.05)。与肿瘤大小无关(P>0.05)。Ki-67标记的指数变化与肿瘤大小无关(P>0.05)。结论本研究显示新辅助化疗抑制肿瘤细胞增殖,促进其凋亡。survivin和Ki-67在新辅助化疗机制中起重要作用。

Objective To observe the change of survivin and Ki-67 of carcinomas after neoadjuvant chernotherapy（NAC） in breast cancer. Methods survivin and Ki-67 were examined by immunohistochemical staining in 37 breast cancer samples. Results The expression of survivin and Ki 67 in post-neoadjuvant chemotherapy[35.14%, （47.25±11.09）%] was signifycantly lower than that in pre-neoadjuvant chemotherapy[67.57%, （67.27±12.17）%] （P〈0.05）. survivin had positive correlation with Ki-67（P〈 0.05） Ki-67 had no correlation with tumor size（P〈0.05）. Conclusion The study shows neoadjuvant chemotherapy inhibites the proliferation and induces apoptosis of breast cancer. Survivin and Ki-67 play important role in the mechanism of neoadjuvant chemotherapy of breast cancer.