盐酸小檗碱与β-环糊精包合性质及热力学研究

Study on berberine/β-cyclodextrin inclusion complex and its thermodynamic properties

The inclusion complexes of berberine hydrochloride with β-cyclodextrin was prepared by the method of saturated aqueous solution,its inclusion complex properties were represented with fluorescence,IR,NMR,X-ray and other spectral approaches.At the same time,the stoichiometric ratio,the constants and the thermodynamic parameters of inclusion complexes were determined.The experimental results demonstrated that a 1:1 inclusion complex of berberine hydrochloride with β-cyclodextrin was formed,and the thermodynamic function change of inclusion process was△G°<0 and△H°<0,the inclusion reaction was a spontaneous exothermal reaction.△S°<0,it was indicated that forming inclusion complex of berberine hydrochloride with β-cyclodextrin is an increased process for degree of order of molecules.Because the berberine hydrochloride/β-cyclodextrin inclusion complex can effectively improve its solubility,decrease side effect and thrill,increase its stability and bioavailability,a useful experimental data is provided for drugs exploitation and understanding interaction mechanism of inclusion complex between berberine hydrochloride and β-cyclodextrin by current work.

The inclusion complexes of berberine hydrochloride with β-cyclodextrin was prepared by the method of saturated aqueous solution,its inclusion complex properties were represented with fluorescence, IR, NMR, X-ray and other spectral approaches. At the same time,the stoichiometrie ratio, the constants and the thermodynamic parameters of inclusion complexes were determined. The experimental results demonstrated that a 1：1 inclusion complex of berberine hydrochloride with β-cyclodextrin was formed,and the thermodynamic function change of inclusion process was △ G° 〈 0 and △ H°〈 0, the inclusion reaction was a spontaneous exothermal reaction. △ S° 〈0,it was indicated that forming inclusion complex of berberine hydrochloride with β-eyelodextrin is an increased process for degree of order of molecules. Because the berberine hydrochloride/β-cyclodextrin inclusion complex can effectively improve its solubihty,decrease side effect and thrill,increase its stability and bioavailability,a useful experimental data is provided for drugs exploitation and understanding interaction mechanism of inclusion complex between berberine hydrochloride and β- cyclodextrin by current work.