培哚普利对糖尿病肾病肾素-血管紧张素系统的影响

The Effects of Perindopril on Renin-angiotensin System in Patients With Diabetic Nephropathy

本研究观察了培哚普利对DN患者RAS影响。44例无高血压、持续有微量白蛋白尿的非胰岛素依赖性糖尿病（NIDDM）患者被随机分为培哚普利治疗组和常规治疗组，培兴普利治疗8周后DN患者增高的RAS活性被抑制，表现为血管紧张素Ⅱ（ATⅡ）水平降低35.8％，PRA增加（P＜0．01），较常规治疗有显著差异。表明培哚普利可抑制DN增高的RAS活性，从而改善DN肾小球血流动力学，降低尿蛋白排泄。

To investigate the effects of perindopril on renin-angiotensin system in patients with diahatic nephropathy, 44 cases of non-insulindependent diabetes mellitus with ndcroalbuminuria and normotensin were randornly divided into two groups: routine group and perindopril group. The study lasted 8 weeks. The results showed that the elevated plasrna angiotensin Ⅱ concentration was makedly decreased by 35.8% and plasrna renin activity had no such effects. This study indicated that perindopril might protect renal function in diabetic nephropathy by inhibiting the renin-angiotensin system.