摘要
目的建立头孢克洛颗粒的体外溶出度测定方法。方法紫外分光光度法测定头孢克洛颗粒的溶出度,以水(37℃)为溶出介质,以浆法(50 r.min-1)为溶出方法,在264 nm测定头孢克洛的溶出度。结果根据上述条件建立头孢克洛颗粒剂的溶出度测定方法。结论所建立的头孢克洛颗粒剂溶出度检查方法可供应用或作为修订标准的参考。
Aim To establish a method for the determination of the dissolution of cefaclor granules. Methods The UV spectrophotometry method was applied to determine the dissolution of cefaclor granules with the water（37℃ ）as the dissolution medium. The paddle method was used which speed was set at 50 r · min^-1 and the sample was measured at 264 nm by UV spectrophotometry. Results The dissolution method of cefaclor granules was established according to the above-mentioned conditions. Conclusion This cefaclor granules dissolution method was useful for the quality control of cefaclor granules.
出处
《安徽医药》
CAS
2009年第1期29-30,共2页
Anhui Medical and Pharmaceutical Journal
关键词
头孢克洛颗粒
溶出度
紫外分光光度法
cefaclor granules
dissolution rate
ultraviolet spectrophotometry
