循环EPCs CD34^+水平与高血压病患者心血管危险因素的关系

Relationship between Circulating EPCs CD34^+ Cells and Cardiovascular Risk in Hypertension

目的探讨能否将循环内皮祖细胞(EPCs)CD34+水平作为评价高血压病患者心血管危险度的标志。方法高血压病患者组62例,对照组20例。高血压病患者采用Framingham心血管危险因素积分分层心血管危险因素,分为低危组18例,中危组14例,高危组17例,极高危组13例。作外周血循环EPCs CD34+水平与Framingham心血管危险因素积分的相关性分析。结果各研究组高血压病患者外周循环EPCs CD34+水平随着其心血管危险程度的增加,逐步下降,各组间比较有统计学意义(P<0.05)。EPCs CD34+水平与Framingham心血管危险因素积分呈负相关关系(r=-0.875,P<0.01)。结论高血压病患者循环EPCs CD34+水平下降与心血管危险因素有显著的相关性。循环EPCs CD34+水平可以作为高血压病患者心血管危险度的标志。

Objective To evaluate whether the variations in the number of circulating endothelial progenitor cells（EPCs）CD34^＋ could be presented as the maker of cardiovascular risk in patients （pts） with hypertension. Methods Sixty - two pts with hypertension and 20 healthy controls were collected. Pts stratified by cardiovascular risk factors according to Framingham risk factors score were divided into lowrisk group （n=18）,mid- risk group （n=14）, high- risk group （n= 17） and much- high- risk group （n = 13）. The level of peripheral circulating EPCs CD34^＋ was measured. The relationships between circulating EPCs CD34^＋ and Framingham cardiovascular risk factors was analyzed. Results The level of peripheral circulating EPCs CD34^＋ was significantly lower in pts with hypertension than that in control group （P〈0.05）, and CD34^＋ cells were inversely correlated with cardiovascular risks. There was a negative correlation between the level of circulating EPCs CD34^＋ and Framingham cardiovascular risk factors（r= -0. 875,P〈0.01）. Conclusion The level of peripheral circulating EPCs CD34^＋ cells was significantly reduced with the increase of score of cardio vascular risk factors . This study demonstrated that the level of circulating EPCs was a predictor of cardiovascular risk in pts with hypertension.