疏血通注射液对心房颤动患者血栓前状态的影响

Effect of Shuxuetong Injection on Prethrombotic State in Patients with Atrial Fibrillation

目的研究疏血通注射液对心房颤动患者血栓前状态的改善作用。方法将63例心房颤动患者随机分为疏血通组和对照组,疏血通组应用疏血通注射液治疗14d,对照组除不使用疏血通,其他用药与疏血通组相同。治疗前和治疗2周后测量两组血浆纤溶酶原激活物(tPA)及其抑制物(PAI-1)活性,D-二聚体(D-D)和血管性假血友病因子(vWF)水平。结果疏血通组和对照组在治疗前血浆tPA、PAI-1活性、D-D和vWF水平无统计学意义(P>0.05)。疏血通组治疗后血浆tPA活性显著性增高(P<0.05),血浆PAI-1活性、D-D和vWF水平均显著性下降(P<0.05),而对照组无显著性改变(P>0.05)。组间比较发现,疏血通组治疗后血浆PAI-1活性、D-D和vWF水平比对照组更低(P<0.05),而血浆tPA活性无显著增高(P>0.05)。结论短期疏血通静脉输注可以明显改善心房颤动患者的血栓前状态,这可能降低心房颤动患者的血栓栓塞危险。

Objective To investigate the effect of Shuxuetong injection on prethrombotic state in patients with atrial fibrillation. Methods Sixty - three patients （pts） with atrial fibrillation were randomly divided into Shuxuetong group treated with Shuxuetong injection for two weeks and control group. Plasma tissue plasminogen activator （tPA） and plasminogen activator inhibitor- 1 （PAI - 1） activity,D- dimer（D- D） and yon willebrand factor （vWF） level were measured before and 2 weeks after treatment. Results There were no significant differences in the activity of tPA, PAl - 1 ,D - D and vWF level before treatment in 2 groups （P〈0.05）. Shuxuetong group had significantly lower PAI- 1 activity,D - D and vWF level than that in control group after treatment （P〈0.05） ,but there was no significant difference in tPA activity（P〈0. 05）. In Shuxuetong group, plasma tPA activity significantly increased （P〈0.05）, PAI - 1 activity, D- D and vWF level significantly decreased after treatment （P〈0.05）, There were no significant differences in control group （P〈0.05 ）. Conclusion Shuxuetong injection could improve prethrombotic state in pts with atrial fibrillation and this might contribute to decrease risk of thrombosis.