布洛芬混悬剂的制备及稳定性研究

PREPARATION AND STABILITY OFIBUPROFEN SUSPENSION

以羟丙基甲基纤维素（ＨＰＭＣ）为助悬剂制备布洛芬混悬剂，经Ｈａｋｋｅ粘度测定仪测定为假塑性流体，加速离心后沉降容积比为０．９５。４０℃加速试验３个月，药物含量稳定，粒径分布经ＴＡⅡ型库尔特计数器测定，ｄ５０为３．２μｍ，加速试验１、２、３个月，ｄ５０分别为３．４、３．２、３．５μｍ，无明显变化。

Ibuprofen suspension was prepared with hydroxypropylmethylcellulose(HPMC) as dispersing agent and behaved as a pseudoplastic fluid by Hakke viscotester. The sedimentation volume ratio was 0.95 after centrifuge. The diameter distribution was determined by coulter counter (TAⅡ) and d50 was 3.2 μm. After the accelerated tests at 40℃ 75%RH for 3 months, there were no significant changes in the diameter distribution, and the preparation was stable.