摘要
目的:观察慢性非瓣膜心房颤动患者血浆TNF-α、IFN-γ的变化,探讨炎症与慢性非瓣膜心房颤动的关系。方法:45例住院患者分为持续性非瓣膜心房颤动组(NVAF组)24例,对照组(非房颤组)21例。检测其血浆TNF-α、IFN-γ水平并对结果进行统计学分析。结果:NVAF组TNF-α(0.08±0.04和0.10±0.02)、IFN-γ(0.10±0.02和0.13±0.02),(均P<0.05)均显著高于对照组,且两者呈直线相关关系。结论:炎症反应参与慢性非瓣膜心房颤动的发生与发展过程。
Objective :To observe the changing of TNF-α and IFN-γin patients with chronic non-valvular atrial fibrillation (NVAF) and explore the relationship of inflammation and NVAF. Methods:Forty five patients were divided into NVAF group (n = 24) and non AF group(n = 21 ). The levds of TNF-α and IFN-γ were measured. Results:The levels of plasma TNF-α and IFN-γ of NVAF group are significant higher than those of non-AF group(31.96 ± 16.58 vs 19.24 ± 7.60,P〈0.05) and (27.75 ± 11.05 vs 19.48 ± 5.99, P〈0.05 ) . And there was a linear regression relationship between plasma TNF-α and IFN-γ(r = 0. 825,P〈0.01 ) Conclusion:There is an association between inflammation and chronic non-valvular atrial fibrillation.
出处
《中国临床医学》
北大核心
2008年第6期756-757,共2页
Chinese Journal of Clinical Medicine