血管内皮生长因子在癌旁组织中的表达与肝细胞癌术后预后相关

High Expression of VEGF in Peritumoral Liver Tissue Is Associated With Poor Survival After Curative Resection of Hepatocellular Carcinoma

目的:研究血管内皮细胞生长因子(VEGF)在肝癌组织及癌旁肝脏组织的表达情况与肝细胞肝癌预后的关系。方法:收集在我所接受肝切除手术并术后病理证实为肝细胞癌的101例患者标本,应用组织芯片和免疫组织化学等方法研究肝癌及癌旁组织VEGF的表达情况,并评价其与临床预后的关系。结果:癌旁组织VEGF的表达明显高于癌组织,癌旁组织VEGF的高表达是患者死亡(P=0.027,风险比(HR)2.356,95%可信区间(CI)1.101～5.040)和复发(P=0.023,HR:2.091,95%CI:1.106～3.950)的独立危险因素。结论:VEGF在癌旁组织中的高表达与肝细胞癌术后肿瘤复发和低生存期显著相关,提示研究癌旁组织的血管生成微环境在肝癌复发转移研究方面的重要性。

Objective：To investigate the prognostic values of the intratumoral and peritumoral expression of vascular endotheli al growth factor （VEGF） in hepatocellular carcinoma （HCC） patients after curative resection. Methods： Expression of VEGF was assessed by immunohistochemistry in tissue microarrays containing paired tumor and peritumoral liver tissue from 101 pa tients who had undergone hepatectomy for histologically proven HCC. Prognostic value of these and other elinicopathologic fac- tors was evaluated. Results： Intratumoral VEGF was not associated with overall survival （OS） or tumor recurrence. High peritumoral VEGF, correlated with microvascular invasion, was an independent prognostic factor for both OS （P = 0. 027） and disease recurrence （P = 0. 023）. Conclusion： High peritumoral VEGF were associated with HCC progression, disease recurrence, and poor survival after hepatectomy, highlighting the importance of peritumoral tissue in the recurrence and metastasis of HCC. VEGF may be targets of postoperative adjuvant therapy.