精神分裂症的人类白细胞抗原病因学研究

Research on the relationships between schizophrenia and human leucocyte antigen.

目的研究精神分裂症与人类白细胞抗原（ＨＬＡ）的关系方法用国际标准微量淋巴细胞毒实验方法对２３例北京地区的精神分裂症患者进行ＨＬＡ分型研究，并与４９例健康对照者进行比较。结果精神分裂症患者Ｂ２７、Ａ９、ＤＱ２抗原频率高，并且Ｂ２７抗原在两组中差异显著。未发现各亚型之间有不同的相关抗原。结论ＨＬＡ与精神分裂症的发生有关，Ｂ２７、Ａ９抗原表型者患精神分裂症的危险性高（ＲＲＢ２７＝５．６５，ＲＲＡ９＝２４７）。

Objective In order to study the relationships between human leucocyte antigen(HLA) and schizophrenia, and explore the HLA antigens associated with schizophrenia. Methods 23 schizophrenia in nearby Beijing area were investigated by the standard microlymphocytotoxicity technique, and compared with 49 healthy volunteers (control group). Results It was showed that the antigen frequences of B27, A9, DQ2 were higher in schizophrenia and the difference of B27 between the patients and control group was significant. But the differences among the subgroups of schizophrenia were not marked. Conclusions It is considered that schizophrenia is associate with HLA and this relationship is complicated. Those people with HLA-B27, A9 have higher risks to schizophrenia(by 5.65 and 2.47, respectively).