钠曲线透析对维持性血液透析患者顽固性高血压的治疗效果

Clinical effect of sodium-curve hemodialysis on sustained hemodialysis patients with refractory hypertension

目的探讨钠曲线透析和序贯透析对维持性血液透析患者并发难治性高血压的临床疗效。方法31例伴难治性高血压维持性血液透析患者按计算器产生随机数字分为钠曲线透析组16例和序贯透析组15例，比较2组患者治疗前后平均动脉压、血容量下降率和红细胞压积以及血管紧张素Ⅱ的变化。结果与治疗前相比，治疗后钠曲线透析和序贯透析在平均动脉压水平较治疗前明显下降，差异有统计学意义（P〈0．01）。治疗后2组比较平均动脉压水平，钠曲线透析较序贯透析组明显下降，差异有统计学意义（P〈0．05）；在血容量下降率、红细胞压积，钠曲线透析较序贯透析组有所降低，其差异无统计学意义（P〉0．05）。钠曲线透析组血管紧张素Ⅱ下降较序贯透析明显，具有统计学意义（P〈0．05）。结论在维持性血液透析患者顽固性高血压的控制上钠曲线透析效果更好。

Objective To observe the clinical effects of sodium-curve hemodialysis and UF-HD dialysis for treatment of sustained hemodialysis patients with refractory hypertension. Methods Thirty-one patients with refractory hypertension were randomly divided into two groups ： sodium-curve hemodialysis group and UF-HD dialysis group. Results of pre- and post-treatment MAP, dBV%, Hct, Ang-Ⅱwere compared between the 2 groups. Results After three months, the post-treatment of MAP in sodium-curve hemodialysis group was significantly lower than that in UF-HD dialysis group （ P 〈 0.05 ）. Conclusion Sodium-curve hemodialysis is a better therapy for sustained hemodialysis patients with refractory hypertension than UF-HD dialysis.