云南美登木内生真菌Phomopsis sp．Lz42的化学成分

Chemical Constituents from Endophytic Phomopsis sp. Lz42 of Maytenus hookeri

从云南美登木内生真菌Phomopsis species Lz42的琼脂平板发酵物中分离得到2个倍半萜和5个麦角甾醇类化合物(1～7),其中化合物1和2为新化合物.应用波谱技术确定其结构为4-Deacetyl-10-oxo-di-hydrobotrydial(1)和麦角甾-6,22-二烯-5α,8α-环二氧-3-甲酸酯(2).

Endophytes, commonly present in higher plants, are important sources of natural products with pharmaceutical potential. A new sesquiterpenoid, 4-deacetyl-10-oxo-dihydro-botrydial（1） , and a new sterol, 22E ,24R-5α, 8α-epidioxyergosta-6,22-dien-3β-formate （2） , were isolated from solid cultures of an endophytie fungal strain Phomopsis species Lz42, cultivated on Maytenus hookeri, together with five related known compounds, 4β-acetoxy-9β-10β-15α-trihydroxyprobotrydial （3）, 22E, 24R-5α, 8α-epidioxyergosta-6,22-dien-3β- ol （4）, ergosterol （ 5 ）, 22E, 24R-ergosta-7,22-diene-3β, 5α, 6β-triol （ 6 ） and 22E, 24R-ergosta-7,22-diene- 3β,5α,6β,9α-tetraol（7）. Their structures were identified by extensive spectroscopic, experiments especially 2D-NMR.