新型温度敏感性自组装胶束P(NiPAAm-co-DMAA)-co-P(L-Ala)的合成和性能

Synthesis and Properties of Novel Temperature-sensitive Self-assemble Nanomicelles of P(NiPAAm-co-DMAA)-co-P(L-Ala)

通过原子转移自由基聚合(ATRP)合成了一种带有活性—NH2基团的温度敏感性亲水型共聚物P(NiPAAm-co-DMAA),并将其作为引发剂,合成了P(NiPAAm-co-DMAA)-co-P(L-Ala),其分子量分布(PDI)在1.3左右.聚合物通过自组装形成纳米胶束.透射电镜(TEM)结果表明,胶束大小200～300nm,具有明显的核壳结构.共聚物的最低临界溶解温度(LCST)为45.5℃.温度低于LCST时,聚合物溶解形成胶束;高于LCST时,胶束解离,聚合物不溶.聚合物对温度的响应是快速而可逆的.

A novel temperature-sensitive amphiphilic copolymer of P（NiPAAm-co-DMAA） with active -NH2 group was synthesized by ATRP, which was used as initiator of amino acid polymerization. The PDI of P（NiPAAm-co-DMAA）-co-P（L-Ala） is about 1.3. This polymer could form temperature-sensitive micelle by self-assembly. The diameter and distribution of micelle were observed by TEM. The results show that the siza of micelle is about 200-300 nm and the micelle has obvious core-shell structure. LCST of copolymer is 45.5 ℃. When temperature is under LCST, the copolymer is soluble and form temperature-sensitive micelle. When temperature is above LCST, the micelle dissociate and copolymer is insoluble. Its response to temperature is quickly and reversible.