含铋复合材料对幽门螺杆菌的多联治疗的研究

Research on the application of inorganic bismuth nanocomposites in multiple-inhibition against H. pylori

将以具有链状高分子结构的柠檬酸铋为模板和前体合成出本身具有抑菌活性的含铋纳米材料,并以此为载体,通过吸附、填充、化学结合等方法与药物小分子或抗生素形成复合材料.研究含铋纳米材料和小分子复合过程的相互作用.评价含铋纳米材料在复合前后对幽门螺杆菌生长的抑制活性的变化.初步研究在模拟生理条件下,纳米材料分解和释放药物的过程,为研究开发新的治疗消化性溃疡疾病的药物提供新的思路.

Different bismuth nanomaterials will be synthesized and characterized using bismuth citrate as a template and bismuth precursor, which has linear polymeric structure. Based on this, nanoeomposite materials with antibiotics or small molecules will be designed through adsorption, filling and chemical bonding. The interactions between bismuth nanomaterials and small moleeules will be discussed. The inhibitory activities against H. pylori of bismuth nanomaterials and nanocomposites will be evaluated. Also we will focus on the primary studies on the process of the decomposition of nanocomposites and drug release under a simulated physiological conditions. It can provide a new idea for the research and development of new drugs in the treatment of peptic ulcer disease.