西比灵与丙戊酸钠预防性干预偏头痛患儿疗效观察

Prospective,randomized and comparative study on the sibelium and valproate prophylactic treatments for children with migraine

目的研究偏头痛儿童的预防性药物干预,探讨安全而有效的干预方法。方法采取前瞻、随机、对照、开放性的研究,将2003年7月至2005年9月在复旦大学附属儿科医院神经内科门诊就诊的200例需要干预治疗的中度偏头痛患儿随机分为两组,分别选用西比灵(氟桂利嗪)和丙戊酸钠,干预2个月后,采用《儿童生活质量量表PedsQl4.0》和头痛指数两项指标来考核疗效。结果生活质量得分情况:西比灵组总分从干预前(68.27±11.06)升至干预后(82.07±5.36),丙戊酸钠组总分从(71.82±9.03)升至(82.74±5.36),差异均有统计学意义(P<0.05);两组间生活质量改善效果相似(P>0.05)。头痛发作指数改变情况:西比灵组从(10.45±7.25)降至(2.20±2.75);丙戊酸钠组从(9.81±7.58)降至(2.03±2.50),差异均有统计学意义(P<0.05);两组间改善效果相似(P>0.05)。结论合理有效的预防性治疗方法将大大改善偏头痛患儿的生活质量并减轻头痛指数,西比灵和丙戊酸钠对偏头痛儿童的预防均有效。

Objective To assess the efficacy of pharmacological prophylactic treatments for migraine in children, and to study an appropriate and safe therapy benefitial to pediatric migrainuer. Methods PedsQ14. 0 and headache index were used to assess the effect of Sibelium （Flunarizine） and valproate （VPA） after provided to the children with migraine. The two groups of 200 moderate migrainuers were compared in a prospective, randomized, controlled and open-label trial. Resuits With the aspect of comparision between sibelium and VPA,both showed effects on increasing the quality of life of children with migraine. Total score of with Sibelium increased from 68. 27 ± 11.06 to 82. 07 ± 5.36 ,while the group with VPA increased from （ 71.82 ± 9. 03 ） to （ 82. 74 ± 5.36 ）. Each group P 〈 0. 05, within group P 〉 0. 05. The two pharmacological ways were also effective to decrease the index of headache. The group with Sibelium decrease from （ 10. 45 ± 7. 25） to （2. 20 ±2. 75） ; the group with VPA decreased from （9. 81 ±7.58） to （2. 03 ±2. 50） ,Each group P 〈0. 05, within group P 〉 0. 05. Comparing the two groups, there were no significance about quality of life and headache index. Conclusion Children with migraine benefit from appropriate prophylactic therapy. Sibelium and VPA could also be used for children with migraine.