N-(取代苯基)马来海松酸酰亚胺的合成及表征

Synthesis and Characterization of N-(Substituted phenyl)maleopimarimide

松香树脂酸衍生物具有广泛的生物活性。该文以松香为原料，在催化剂对甲基苯磺酸作用下与马来酸酐经Diels—Alder反应制得马来海松酸；马来海松酸与取代苯胺采用一步法在N，N-二甲基甲酰胺（DMF）溶剂中，于155℃反应4h，合成了8个具有潜在生物活性的N-（取代苯基）马来海松酸酰亚胺化合物，产率为42．5％～84．8％；对产物结构进行了IR、^1HNMR、^13CNMR光谱表征确认。

Pine resin acids have extensive bioactivities. In the presence of p-toluenesulfonic acid as catalyst, maleopimaric acid is synthesized by Diels-Alder reaction from rosin. With N, N- dimethylformamide （DMF） as solvent, eight N-（ substituted phenyl） maleopimarimide compounds with potential bioaetivities are synthesized from maleopimaric acid and substituted aniline by one-step reaction under 155 ℃ for 4 h. Yields of eight N-（ substituted phenyl）maleopimarimide compounds are 42.5% -84. 8%. Their structures were confirmed by IR, ^1HNMR and ^13CNMR spectroscopy.