PD-1／PD-L与慢性病毒性肝炎

PD-1/PD-L and chronic virus hepatitis

PD-1／PD—L信号途径在保持对机体自身成分的免疫耐受中发挥作用，同时在对外来抗原的免疫反应中发挥负向调控作用。病毒慢性持续感染、T细胞耗竭、T细胞或其它组织细胞PD-1／PD—L表达的增加常同时俘在。肝脏多种非实质细胞和肝细胞均可表达PD-L1，具有抑制T细胞活性的作用。目前，PD-1／PD—L与慢性病毒性肝炎的发病机制和治疗对策关系的研究方兴未艾。

Signal pathway of programmed deathl/programed death-L （PD-1/PD-L） play a role in maintaining the immune olerance to self components in the organism, and it also play a negative role in the regulation and control of the immune responses to alien antigens. Some events such as the chronic persistent virus infection, T cell exhaustion, and the increased expression of PD-1/PD-L in T cell or other organizations often occurred simultaneously. PD-L1 expresses in many kinds of mesenchyma and parenchyma ceils in liver, and it can also inhibit the activity of T cells. The relationship between the PD-1/PD-L and the pathogenesis and treatment of chronic viral hepatitis are in the asceudant.